Ranking novel cancer driving synthetic lethal gene pairs using TCGA data
نویسندگان
چکیده
منابع مشابه
Ranking novel cancer driving synthetic lethal gene pairs using TCGA data
Synthetic lethality (SL) has emerged as a promising approach to cancer therapy. In contrast to the costly and labour-intensive genome-wide siRNA or CRISPR-based human cell line screening approaches, computational approaches to prioritize potential synthetic lethality pairs for further experimental validation represent an attractive alternative. In this study, we propose an efficient and compreh...
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BACKGROUND The Cancer Genome Atlas (TCGA) Data portal provides a platform for researchers to search, download, and analysis data generated by TCGA. The objective of this study was to explore the molecular mechanism of ovarian cancer pathogenesis. METHODS Microarray data of ovarian cancer were downloaded from TCGA database, and Limma package in R language was used to identify the differentiall...
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The Publisher and Editor regretfully retract this article (Ying H, Lv J, Ying T, Jin S, Shao J, Wang L, et al. Gene-gene interaction network analysis of ovarian cancer using TCGA data. J Ovarian Res. 2013;6:88) because the peer-review process was inappropriately influenced and compromised. As a result, the scientific integrity of the article cannot be guaranteed. A systematic and detailed inves...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10536